Square-Enix is going all-out on Trials of Mana, revamping all sorts of areas in the game. There's really a lot to offer, and some of that depends on who you choose to take with you on the journey. In an interview with Vooks, Square-Enix's Shinichi Tatsuke talks about how you arrive at the game's multiple endings.
First of all, the prologues for each of the six characters are completely different and the game also has multiple endings, depending on what combination of characters that you choose. But the story will also change, depending on that character combination.