Yes, even though we're nearing the three-year mark for The Legend of Zelda: Breath of the Wild, people are still digging away at the game to see how they can bend it to their will. Yet another glitch has been discovered, and this one lets you take out Ganon with just a single hit.
The glitch has to do with an issue during cut-scenes. Turns out Nintendo forgot to turn off enemy damage during cut-scenes. This means if you line up a shot/hit just right, the enemy you've attacked will continue to take damage during the entire cut-scene. The end result is a dead enemy, no matter how big and strong they are. That's how you get to video above, which shows Ganon being dealt with like any other common enemy.