DOOM Eternal carries on from DOOM (2016) with the same protagonist, but the team behind the game were heavily considering taking things in another direction. In an interview with Bethesda's community manager, Doom Eternal director Hugo Martin mentions that there was a lot of thought about a female DOOM Slayer.
“I’ve thought about it, actually. I think if we did it, I’d want it to be lethal. I think it’s interesting how it would impact the glory kills, the kind of weapons that she would have, the fighting style. All aggression, absolutely, but a different type of aggression. I would really strive to allow it to impact the gameplay in a way that was meaningful. I’ve definitely put a lot of thought into that. How would that affect things? What sort of analogies could you draw from that and allow that to influence the experience? It definitely would be cool.”
Obviously the female direction didn't happen, but it sounds like an idea the team would love to explore going forward. We'll just have to hang back for the inevitable DOOM Eternal follow-up to see what happens.